The phrase 'Against all odds' means despite very low probability; in a most unlikely way. Example of use: "She managed to win the trophy against all odds."

If you do or achieve something against (all) the odds/against all odds, you do or achieve it although there were a lot of problems and you were not likely to succeed: Against all the odds, he recovered.

The pair played brothers onscreen for 15 seasons, but it's clear that their friendship extends offscreen as well. In 2007, Padalecki told TV Guide that the reason the actors work so well together is because they're "really good buddies." He said, "... That's been probably the best thing about Supernatural.

The Supernatural stars married their soul mates in the same year  2010  and since then, Genevieve Padalecki (ne Cortese) and Danneel Ackles (ne Harris) have become incredibly close.