The slots with the highest RTP rates at licensed US online casinos are: Blood Suckers (98%), Starmania (97.87%), White Rabbit (97.72%), Medusa Megaways (97.63%), Guns N' Roses (96.98%), Blood Suckers 2 (96.94%), Jimi Hendrix (96.9%), Butterfly Staxx (96.8%), Dead or Alive (96.82%) and Fruit Shop (96.7%).

Essentially, the looser the slot machine, the more money it returns to the player. That said, a loose slot doesn't mean the player has any additional advantage over the house. The casino still has an edge on your play, but looser slots offer better returns.